Prof. Kazuhiko Igarashi
Prof. Igarashi's research stemmed from interests in cell differentiation during his training at a medical school. Prof. Igarashi took graduate trainings at Tohoku University (Prof. Hiroshi Okamoto) and National Institute of Genetics, Japan (Prof. Akira Ishihama), and postdoctoral training at the University of Chicago, USA (Prof. Bernard Roizman). After serving as Assistant Professor at Tohoku University (with Prof. Norio Hayashi), Lecturer at Tsukuba university (with Prof. Masayuki Yamamoto), Associate Professor at Tohoku University (with Prof. Norio Hayashi), and Professor at Hiroshima University School of Medicine, he moved back to Tohoku University in 2005 and has been leading the Department of Biochemistry.
Member of Japan Biochemical Society, Molecular Biology Society of Japan, Japanese Cancer Association, and American Society for Biochemistry and Molecular Biology. Editorial board member of Journal of Biological Chemistry.
Akihiko Muto, Associate Professor
Gene regulatory network of B cells, single cell analysis
I am focusing on to reveal the roles of transcription factor Bach2 which is required for class switch recombination in activated B cells (Muto 2010 EMBO J). Not only does Bach2 inhibit plasma cell differentiation by repressing Blimp-1 expression (Tanaka 2016 J Biol Chem), but it also regulates survival and proliferation of B cells (Miura 2018 J Immumol).
Kyoko Ochiai, Assistant Professor
Gene regulatory network and chromatin of B cells
my goal of research are: 1) to discover the new function of B cells for body homeostasis mechanism; 2) to develop the clinical application using the mechanism.
Mitsuyo Matsumoto, Assistant Professor (collaborative project)
cancer metastasis, bioinformatics
I am interested to find out biomarkers that are useful for cancer diagnosis. Now, my research focuses on the effects of BACH1 in cancer cells and therapeutic strategy based on its effects.
Dr. Hiroki Shima
Epitranscriptome, mass spectrometry
I am focusing on the feedback regulation of the expression of MAT2A, the mammalian S-adenosylmethionine synthetase, through intracellular SAM-responding methylation of its mRNA, and also am interested in the reason why SAM production must be regulated so strictly in living cells.
Dr. Hironari Nishizawa
Cancer gene regulation
My research focuses on the regulation of ferroptosis by BACH1 and the influence of BACH1 and ferroptosis on cancer and biological function.
Dr. Stephanie Kaypee
Chromatin, B cells
My research focuses on understanding the role of chromatin plasticity in lineage restriction using the plasma cell differentiation model.
Ms. Rie Meguro
Support
自己紹介、将来展望など introduction, perspectives etc
Yusho Ishii, D4
Molecular basis of autoimmune diseases
I am investigating how Mat2 affects immune system through epigenome modifications, and finding out new therapeutic targets for autoimmune diseases.
Long Nguen, D4
Epigenetics, metabolism
My major focus is to understand the epigenetic regulation in cancer cell biology, centered on One Carbon Metabolism. My biggest mission is to unveil the secrets behind the nuclear localization of SAM synthesis process in cells.
Mahabub Alam, D2
Epigenetics, metabolism
My research focuses on protein-RNA interaction and the biological meaning of interaction implicating post-transcriptional modifications. On leave from Assistant Professor, Chittagong Veterinary and Animal Sciences University, Bangladesh.
Liang Liu, D2
Regulation of transcription factors
My research focuses on the understanding of heme-responsive ubiquitination of Bach1 and the effects on genes regulated by Bach1.
Masahiro Rokugo, D2
Cancer metastasis
自己紹介、将来展望など introduction, perspectives etc
Keisuke Tada, D2
Regulation of SAM synthesis in cell responses
My research focuses on the connection between metabolism and SAM synthesis. I hope to find targets for therapy in the crossroad of nutrition and cell damages.
Rikako Kitazawa, M2
Transcription factors for B cells
自己紹介、将来展望など introduction, perspectives etc
Zobidah YOUSIF ELAMIN YOUSIF, M2
Epigenetics, metabolism
自己紹介、将来展望など introduction, perspectives etc
Tomohiro Osada, M1
cancer gene regulation
My interests in cancer biology led me to the master degree program. I am currently investigating the functions of the BACH family in cancer cell transformation.
Kazuki Nara, Medical Student
epigenetics, HTS
The complexity of life drives me to do basic research. I am longing for the finding which fascinates me for my whole life.
Aoi Hozumi, Medical Student
RNA methylation
自己紹介、将来展望など introduction, perspectives etc
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