All of the diverse cells in our body contain the same genome but can play cell type-specific roles by expressing unique sets of genes. We are tyring to understand how the expression of 20,000 protein coding genes in human genome is coordinated during the processes of cell differentiation and responses.
We are focusing on DNA binding transcription factors and their co-factors including chromatin-related enzymes. We are also working on posttranscriptional methylation of messenger RNA. Model systems we use range from hematopoietic stem and progenitor cells to mature cells including red blood cells and B lymphoid cells. Cancer biology as deregulation of gene expression is also our focus. We combine biochemistry, molecular biology, mass spectrometry, next generation sequencing and bioinfomatics approaches.
We hope to understand cell differentiation and diseases such as cancer and anemia based on gene regulatory network (GRN) and its derangement. We support education and training of next generations through research programs.