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東北大学医学系研究科 生物化学分野

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2012年2月12日
大学院生・李さんが論文を発表:Regulation of mitotic chromosome by nuclear export signal of Bach1

Bach1 has been analyzed as a transcriptional repressor, which regulates transcriptional responses against cellular stresses. Here, we found that Bach1 has a novel role for mitotic chromosome alignment during metaphase. Interestingly, this activity does not require DNA binding activity of Bach1 and rather requires its nuclear export signal (NES). Our finding suggests that Bach1 might mediate the possible regulation of mitotic chromosomes under cellular stresses. We will focus on the role of Bach1 in stress-mediated diseases such as cancer, aging, and radiation injury.

Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism. Li J., Shiraki T., and Igarashi K. FEBS Letter in press

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